Haynes B F, Hensley L L, Jegasothy B V
Blood. 1982 Aug;60(2):463-73.
Using a panel of monoclonal antibodies, we have studied cell surface antigens of infiltrating mononuclear cells in skin biopsies from patients with cutaneous T-cell lymphoma (CTCL) and compared them with the T-cell surface phenotype seen in benign cutaneous T-cell infiltrations (e.g., contact dermatitis, delayed hypersensitivity skin tests, granuloma annulare) and in dermal infiltrates of lymphomatoid granulomatosis patients. We found that unlike circulating CTCL (Sézary) cells, CTCL cells infiltrating skin epidermis frequently expressed the T-cell antigen 3A1. Cutaneous infiltrates in 10 patients with mycosis fungoides (MF) and 1 patient with Sézary syndrome were OKT4 (inducer T cell), OKT8 (suppressor/cytotoxic T cell); 2 patients with MF were OKT4-, OKT8; and one MF patients's skin T cell were OKT4-, OKT8+. Similar to CTCL infiltrating cells, most of the benign skin T-cell infiltrates were usually 3A1+. OKT4+, and OKT8-. Our study shows the complex nature of T-cell antigen patterns in inflammatory and malignant skin T-cell infiltrations. We demonstrated that the CTCL the skin epidermal infiltrating T-cell phenotype is not invariate, and in many cases, is similar to the phenotype of clinically benign cutaneous T-cell infiltrations.
我们使用一组单克隆抗体，研究了皮肤T细胞淋巴瘤（CTCL）患者皮肤活检中浸润性单核细胞的细胞表面抗原，并将其与良性皮肤T细胞浸润（如接触性皮炎、迟发型超敏皮肤试验、环状肉芽肿）以及淋巴瘤样肉芽肿病患者真皮浸润中的T细胞表面表型进行了比较。我们发现，与循环中的CTCL（Sezary）细胞不同，浸润皮肤表皮的CTCL细胞经常表达T细胞抗原3A1。10例蕈样肉芽肿（MF）患者和1例Sezary综合征患者的皮肤浸润细胞为OKT4（诱导性T细胞）、OKT8（抑制性/细胞毒性T细胞）；2例MF患者为OKT4阴性、OKT8阴性；1例MF患者的皮肤T细胞为OKT4阴性、OKT8阳性。与CTCL浸润细胞相似，大多数良性皮肤T细胞浸润通常为3A1阳性、OKT4阳性和OKT8阴性。我们的研究显示了炎症性和恶性皮肤T细胞浸润中T细胞抗原模式的复杂性。我们证明，CTCL皮肤表皮浸润性T细胞表型并非一成不变，在许多情况下，与临床良性皮肤T细胞浸润的表型相似。
