Ngwenya B Z
Parasite Immunol. 1982 May;4(3):197-207. doi: 10.1111/j.1365-3024.1982.tb00431.x.
Infection with Trichinella spiralis larvae greatly enhanced the resistance of adult mice against fatal infection with Plasmodium berghei given 10 and 30 days after T. spiralis infection. Mice infected with T. spiralis had a markedly activated mononuclear phagocytic system and significantly low reticulocyte levels at the time the mice were challenged with P. berghei. Therefore, the partially subdued parasitaemia and prolonged survival of Trichinella-Plasmodium-infected mice may be attributed, in part, to macrophage activity and reticulocytopenia exerting a specific anti-P. berghei effect. This study suggests the role of T. spiralis induced reticulocytopenia and activated macrophages as potential mechanisms in resistance to P. berghei infection.
旋毛虫幼虫感染极大地增强了成年小鼠对伯氏疟原虫致死性感染的抵抗力，这种抵抗力在旋毛虫感染后10天和30天给予伯氏疟原虫时表现出来。感染旋毛虫的小鼠在受到伯氏疟原虫攻击时，单核吞噬细胞系统明显激活，网织红细胞水平显著降低。因此，旋毛虫-疟原虫感染小鼠的寄生虫血症部分受到抑制以及存活时间延长，可能部分归因于巨噬细胞活性和网织红细胞减少发挥了特异性抗伯氏疟原虫作用。本研究表明，旋毛虫诱导的网织红细胞减少和激活的巨噬细胞作为抵抗伯氏疟原虫感染的潜在机制发挥了作用。
