Chenchev I, Kostov G, Cholakova R, Bonovska M
Vet Med Nauki. 1981;18(10):104-8.
Attempts to stimulate the immunity against Newcastle disease in birds aged 2 months, of the Leghorn breed, were carried out. It was found that levamisol at the rate of 3 mg/kg body weight given once, parenterally, 24 hours prior to or after the immunization of the birds with a live La Sota vaccine or given three times, parenterally or orally, did not stimulate the humoral immune response. No differences were found in the level of the total protein, protein fractions, and the titer of the hemagglutinating antibodies between the test and the control birds. There was, however, prolongation of the time of effective immunity in the levamisol-treated and vaccinated birds as against the birds that were vaccinated against Newcastle disease only. Discussed in the possible mechanism of stimulating the immunity with levamisol.
对2月龄来航鸡进行了刺激其抗新城疫免疫力的尝试。结果发现，在给鸡用活La Sota疫苗免疫前或免疫后24小时，以3毫克/千克体重的剂量单次非肠道给予左旋咪唑，或以同样剂量非肠道或口服给予三次，均未刺激体液免疫反应。在试验组和对照组鸡之间，总蛋白水平、蛋白组分以及血凝抗体滴度均未发现差异。然而，与仅接种新城疫疫苗的鸡相比，经左旋咪唑处理并接种疫苗的鸡的有效免疫时间有所延长。文中讨论了左旋咪唑刺激免疫的可能机制。
