Dorchy H, Despontin M, Haumont D, Toussaint D, Loeb H
Arch Fr Pediatr. 1982 Mar;39(3):145-8.
This study concerned 74 diabetic children and adolescents, ages ranging from 3 to 21 years. Duration of the disease ranged from 1 month to 15 years. Blood samples were taken during a 12 month period of observation. 292 immunoreactive C-peptide (CPR) evaluations showed a residual endogeneous secretion of insulin in 57% of cases. CPR and duration of diabetes were negatively correlated (r = -0.35; p less than 0.01); however, even 5 years after onset of the disease, a residual beta-cell activity could be observed. CPR was not related with blood glucose, triglyceride, cholesterol or glycosylated hemoglobin levels. On the other hand, CPR was statistically higher in patients whose diabetes had been well-controlled from the onset of the disease, according to clinical criteria, and in those who did not present with retinopathy: however they were also the patients with the shortest duration of disease.
本研究涉及74名糖尿病儿童和青少年，年龄在3至21岁之间。病程从1个月到15年不等。在12个月的观察期内采集血样。292次免疫反应性C肽（CPR）评估显示，57%的病例存在胰岛素残余内源性分泌。CPR与糖尿病病程呈负相关（r = -0.35；p < 0.01）；然而，即使在疾病发作5年后，仍可观察到残余的β细胞活性。CPR与血糖、甘油三酯、胆固醇或糖化血红蛋白水平无关。另一方面，根据临床标准，从疾病发作起糖尿病得到良好控制的患者以及未出现视网膜病变的患者，其CPR在统计学上较高：然而他们也是病程最短的患者。
