抗流感病毒基质蛋白抗体可检测出感染甲型流感病毒的细胞表面的一种共同抗原。
Antibody to influenza virus matrix protein detects a common antigen on the surface of cells infected with type A influenza viruses.
作者信息
Biddison W E, Doherty P C, Webster R G
出版信息
J Exp Med. 1977 Sep 1;146(3):690-7. doi: 10.1084/jem.146.3.690.
Abstract
Antisera to the type-specific internal influenza virus matrix (M) protein of a type A influenza virus were produced in goats. In the presence of complement, anti-M serum was cytotoxic for target cells which were infected with a variety of serologically distinct type A influenza viruses, but did not react with type B influenza virus-infected cells. Absorption experiments indicated that anti-M serum detected a common antigen(s) on the surface of type A-infected cells. This serological cross-reactivity parallels the cross-reactivity observed for the cytotoxic T-cell response to type A viruses.
摘要
针对甲型流感病毒特定型别内部流感病毒基质（M）蛋白的抗血清是在山羊体内产生的。在补体存在的情况下，抗M血清对感染多种血清学上不同的甲型流感病毒的靶细胞具有细胞毒性，但不与感染乙型流感病毒的细胞发生反应。吸收实验表明，抗M血清检测到甲型感染细胞表面存在一种共同抗原。这种血清学交叉反应与对甲型病毒的细胞毒性T细胞反应中观察到的交叉反应相似。
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