Fugleberg S, Kølendorf K, Thorsteinsson B, Bliddal H, Lund B, Bojsen F
Diabetologia. 1982 Jun;22(6):437-40. doi: 10.1007/BF00282586.
To investigate the mechanism of insulin degradation in normal subjects, a kinetic model of insulin disappearance was constructed: insulin was assumed to be extracted from plasma by two independent processes, one saturable and one non-saturable. On the basis of these assumptions, a linear (non-proportional) relationship between steady-state plasma insulin concentration and steady-state plasma disappearance rate was predicted over the concentration range studied. Constant infusion experiments were performed on eight healthy normal subjects, normoglycaemia and fasting plasma C-peptide concentrations being maintained during the experiments. Agreement was found between the predictions of the model and the experimental results, and it is concluded that insulin degradation in normal subjects may be described in terms of two processes: one that is saturated at physiological plasma insulin concentrations and one that is apparently non-saturable over a wide concentration range.
为研究正常受试者体内胰岛素降解的机制，构建了胰岛素消失的动力学模型：假定胰岛素通过两个独立过程从血浆中清除，一个是可饱和过程，另一个是非饱和过程。基于这些假设，在所研究的浓度范围内，预测稳态血浆胰岛素浓度与稳态血浆清除率之间呈线性（非比例）关系。对8名健康正常受试者进行了持续输注实验，实验期间维持血糖正常和空腹血浆C肽浓度。发现模型预测与实验结果相符，得出结论：正常受试者体内胰岛素降解可通过两个过程来描述，一个在生理血浆胰岛素浓度下饱和，另一个在较宽浓度范围内明显不饱和。
