Radman M, Jeggo P, Wagner R
Mutat Res. 1982 May;98(3):249-64. doi: 10.1016/0165-1110(82)90035-5.
All carcinogens that have been thoroughly tested have been found to induce some kind of chromosomal rearrangement. Chromosomal rearrangements are associated with a variety of human and rodent cancers and are associated, with in vitro cell transformation. The DNA from non-malignant cells can transform other non-malignant cells under conditions that may involve chromosomal rearrangement. These findings support the view that chromosomal rearrangement can be a step in carcinogenesis. Available evidence indicates that carcinogens can act to induce chromosomal rearrangement by creating or revealing sites on DNA for recombination, or by inducing or activating cellular systems resulting in a stimulation of recombination. Chromosomal rearrangement may affect carcinogenesis by altering gene expression. Perhaps by allowing the activation of cellular cancer genes.
所有经过充分测试的致癌物都已被发现会诱发某种染色体重排。染色体重排与多种人类和啮齿动物癌症相关，并且与体外细胞转化有关。在可能涉及染色体重排的条件下，非恶性细胞的DNA可以转化其他非恶性细胞。这些发现支持了染色体重排可能是致癌过程中的一个步骤的观点。现有证据表明，致癌物可通过在DNA上产生或暴露用于重组的位点，或通过诱导或激活导致重组刺激的细胞系统来诱导染色体重排。染色体重排可能通过改变基因表达来影响致癌作用。也许是通过激活细胞癌基因来实现。
