三磷酸腺苷（ATP）能穿过细胞质膜吗？
Does ATP cross the cell plasma membrane.
作者信息
Chaudry I H
出版信息
Yale J Biol Med. 1982 Jan-Feb;55(1):1-10.
Abstract
Although there is an abundance of evidence which indicates that ATP is released as well as taken up by cells, the concept that ATP cannot cross the cell membrane has tended to prevail. This article reviews the evidence for the release as well as uptake of ATP by cells. The evidence presented by various investigators clearly indicates that ATP can cross the cell membrane and suggests that the release and uptake of ATP are physiological processes.
摘要
尽管有大量证据表明细胞会释放和摄取ATP，但ATP不能穿过细胞膜这一观念却往往占主导地位。本文回顾了细胞释放和摄取ATP的相关证据。不同研究者提供的证据清楚地表明ATP能够穿过细胞膜，这表明ATP的释放和摄取是生理过程。
相似文献
1
Does ATP cross the cell plasma membrane.三磷酸腺苷（ATP）能穿过细胞质膜吗？
Yale J Biol Med. 1982 Jan-Feb;55(1):1-10.
2
Further evidence for ATP uptake by rat tissues.大鼠组织摄取ATP的进一步证据。
Biochim Biophys Acta. 1980 Mar 20;628(3):336-42. doi: 10.1016/0304-4165(80)90383-9.
3
Myocardial nucleotide transport.
Annu Rev Physiol. 1985;47:605-16. doi: 10.1146/annurev.ph.47.030185.003133.
4
[Permeability of the isolated cells to adenyl nucleotides].[分离细胞对腺苷酸核苷酸的通透性]
Boll Chim Farm. 1974 Aug;113(8):428-30.
5
[The effect of the coronary dilator lidoflazine on myocardial adenosine metabolism in ischemia and anoxia].冠状动脉扩张剂利多氟嗪对缺血缺氧心肌腺苷代谢的影响
Arzneimittelforschung. 1972 Nov;22(11):1869-74.
6
7
Adenine nucleotide metabolism in the heart.心脏中的腺嘌呤核苷酸代谢。
Circ Res. 1974 Sep;35 Suppl 3:109-20.
8
The AMP-adenosine cycle is active during normoxia and impaired in ATP depletion in isolated rabbit cardiomyocytes.在离体兔心肌细胞中，AMP - 腺苷循环在常氧状态下活跃，而在ATP耗竭时受损。
Adv Exp Med Biol. 1994;370:323-6. doi: 10.1007/978-1-4615-2584-4_69.
9
10
Release of adenosine by hypoxic canine lung tissue and its possible role in pulmonary circulation.缺氧犬肺组织中腺苷的释放及其在肺循环中的可能作用。
Am J Physiol. 1975 Dec;229(6):1625-31. doi: 10.1152/ajplegacy.1975.229.6.1625.
引用本文的文献
1
Association of Tramadol-Induced Ovarian Damage and Reproductive Dysfunction with Adenosine Triphosphate and the Protective Role of Exogenous ATP Treatment.曲马多诱导的卵巢损伤和生殖功能障碍与三磷酸腺苷的关联及外源性三磷酸腺苷治疗的保护作用
Pharmaceuticals (Basel). 2025 Feb 6;18(2):216. doi: 10.3390/ph18020216.
2
Pathogenesis-directed therapy of methylphenidate-induced oxidative heart damage in rats.哌甲酯诱导大鼠心脏氧化损伤的发病机制导向治疗
Front Pharmacol. 2025 Jan 3;15:1503032. doi: 10.3389/fphar.2024.1503032. eCollection 2024.
3
The Effect of Oral Adenosine Triphosphate (ATP) Supplementation on Anaerobic Exercise in Healthy Resistance-Trained Individuals: A Systematic Review and Meta-Analysis.口服补充三磷酸腺苷（ATP）对健康抗阻训练个体无氧运动的影响：一项系统评价与荟萃分析
Sports (Basel). 2024 Mar 14;12(3):82. doi: 10.3390/sports12030082.
4
Micropeptide ASAP encoded by LINC00467 promotes colorectal cancer progression by directly modulating ATP synthase activity.LINC00467 编码的微肽 ASAP 通过直接调节 ATP 合酶活性促进结直肠癌的进展。
J Clin Invest. 2021 Nov 15;131(22). doi: 10.1172/JCI152911.
5
High-Energy Phosphates and Ischemic Heart Disease: From Bench to Bedside.高能磷酸盐与缺血性心脏病：从实验台到病床边
Front Cardiovasc Med. 2021 Jul 28;8:675608. doi: 10.3389/fcvm.2021.675608. eCollection 2021.
6
Fluorescence Microscopy for ATP Internalization Mediated by Macropinocytosis in Human Tumor Cells and Tumor-xenografted Mice.利用荧光显微镜研究人源肿瘤细胞和异种移植瘤小鼠内吞作用摄取 ATP 的情况
J Vis Exp. 2021 Jun 30(172). doi: 10.3791/62768.
7
Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11.格列本脲、三磷酸腺苷和二甲双胍增加人胆汁盐输出泵 ABCB11 的表达。
F1000Res. 2020 Dec 22;9:1497. doi: 10.12688/f1000research.26632.1. eCollection 2020.
8
The effect of adenosine triphosphate on propofol-induced myopathy in rats: a biochemical and histopathological evaluation.三磷酸腺苷对大鼠丙泊酚诱导的肌病的影响：生化和组织病理学评估
Korean J Physiol Pharmacol. 2021 Jan 1;25(1):69-77. doi: 10.4196/kjpp.2021.25.1.69.
9
Quantum biology in low level light therapy: death of a dogma.低强度光疗中的量子生物学：一个教条的终结
Ann Transl Med. 2020 Apr;8(7):440. doi: 10.21037/atm.2020.03.159.
10
Glucose Drives Growth Factor-Independent Esophageal Cancer Proliferation via Phosphohistidine-Focal Adhesion Kinase Signaling.葡萄糖通过磷酸组氨酸-黏着斑激酶信号驱动生长因子非依赖型食管癌细胞增殖。
Cell Mol Gastroenterol Hepatol. 2019;8(1):37-60. doi: 10.1016/j.jcmgh.2019.02.009. Epub 2019 Mar 2.
本文引用的文献
1
THE POTASSIUM EQUILIBRIUM IN MUSCLE.肌肉中的钾平衡。
J Gen Physiol. 1934 May 20;17(5):629-56. doi: 10.1085/jgp.17.5.629.
2
Potassium accumulation in muscle and associated changes.肌肉中的钾蓄积及相关变化。
J Physiol. 1941 Aug 11;100(1):1-63. doi: 10.1113/jphysiol.1941.sp003922.
3
The in vitro oxidation of pyruvic and alpha-ketobutyric acids by ground preparations of pigeon brain. The effect of inorganic phosphate and adenine nucleotide.鸽脑研磨制剂对丙酮酸和α-酮丁酸的体外氧化作用。无机磷酸盐和腺嘌呤核苷酸的影响。
Biochem J. 1943 Jul;37(2):215-25. doi: 10.1042/bj0370215.
4
Action of DOC and serum on the frog heart.洋地黄毒苷和血清对蛙心的作用。
Am J Physiol. 1952 Jan;168(1):159-70. doi: 10.1152/ajplegacy.1951.168.1.159.
5
The possibility that ATP is a transmitter at sensory nerve endings.ATP作为感觉神经末梢递质的可能性。
J Physiol. 1953 Mar;119(4):50P-51P.
6
Further evidence for ATP uptake by rat tissues.大鼠组织摄取ATP的进一步证据。
Biochim Biophys Acta. 1980 Mar 20;628(3):336-42. doi: 10.1016/0304-4165(80)90383-9.
7
Appearance of adenosine triphosphate in the coronary sinus effluent from isolated working rat heart in response to hypoxia.缺氧时离体工作大鼠心脏冠状窦流出液中三磷酸腺苷的出现情况。
J Physiol. 1981 Mar;312:143-58. doi: 10.1113/jphysiol.1981.sp013621.
8
Control of membrane permeability by external and internal ATP in 3T6 cells grown in serum-free medium.在无血清培养基中生长的3T6细胞中，细胞外和细胞内ATP对膜通透性的调控。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2103-7. doi: 10.1073/pnas.77.4.2103.
9
Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture.培养的血管内皮细胞和平滑肌细胞外切酶对腺嘌呤核苷酸的代谢
Biochem J. 1980 Aug 15;190(2):421-9. doi: 10.1042/bj1900421.
10
Modulation of neurotransmission by purine nucleotides and nucleosides.嘌呤核苷酸和核苷对神经传递的调节。
Biochem Pharmacol. 1980 Jun 15;29(12):1635-43. doi: 10.1016/0006-2952(80)90117-3.
Zotero 插件