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三磷酸腺苷(ATP)能穿过细胞质膜吗?

Does ATP cross the cell plasma membrane.

作者信息

Chaudry I H

出版信息

Yale J Biol Med. 1982 Jan-Feb;55(1):1-10.

Abstract

Although there is an abundance of evidence which indicates that ATP is released as well as taken up by cells, the concept that ATP cannot cross the cell membrane has tended to prevail. This article reviews the evidence for the release as well as uptake of ATP by cells. The evidence presented by various investigators clearly indicates that ATP can cross the cell membrane and suggests that the release and uptake of ATP are physiological processes.

摘要

尽管有大量证据表明细胞会释放和摄取ATP,但ATP不能穿过细胞膜这一观念却往往占主导地位。本文回顾了细胞释放和摄取ATP的相关证据。不同研究者提供的证据清楚地表明ATP能够穿过细胞膜,这表明ATP的释放和摄取是生理过程。

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本文引用的文献

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THE POTASSIUM EQUILIBRIUM IN MUSCLE.肌肉中的钾平衡。
J Gen Physiol. 1934 May 20;17(5):629-56. doi: 10.1085/jgp.17.5.629.
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Potassium accumulation in muscle and associated changes.肌肉中的钾蓄积及相关变化。
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Further evidence for ATP uptake by rat tissues.大鼠组织摄取ATP的进一步证据。
Biochim Biophys Acta. 1980 Mar 20;628(3):336-42. doi: 10.1016/0304-4165(80)90383-9.
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Modulation of neurotransmission by purine nucleotides and nucleosides.嘌呤核苷酸和核苷对神经传递的调节。
Biochem Pharmacol. 1980 Jun 15;29(12):1635-43. doi: 10.1016/0006-2952(80)90117-3.

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