Rudolf Z, Plesnicar S
Anticancer Res. 1982 Jan-Apr;2(1-2):37-9.
Forty three patients with disseminated malignant melanoma were treated by combination chemotherapy with DTIC (800 mg/m2) and subsequent peroral cyclophosphamide (100 mg/m2) for 14 days. Overall response was observed in 18/43 (42%), and complete response in 9/43 (21%) cases. Complete response was achieved mainly in patients with metastatic involvement of lungs. Mean survival from onset of treatment for responding patients was significantly longer than mean survival of nonresponders (15 versus 5 months, respectively). Serious complications were not noted.
43例播散性恶性黑色素瘤患者接受了联合化疗，即先用达卡巴嗪（800mg/m²），随后口服环磷酰胺（100mg/m²），共14天。43例患者中有18例（42%）观察到总体缓解，9例（21%）完全缓解。完全缓解主要见于肺部有转移的患者。缓解患者从治疗开始的平均生存期显著长于未缓解患者（分别为15个月和5个月）。未发现严重并发症。
