Lack of effect of luteinizing hormone-releasing hormone on pancreatic exocrine secretion and release of gastrin and pancreatic polypeptide in dog.

In 7 conscious dogs with gastric and duodenal Thomas fistulas we studied the effect of an intravenous bolus injection of luteinizing hormone-releasing hormone (LHRH, 100 microgram) on pancreatic bicarbonate and protein secretion stimulated by an intravenous infusion of secretin (500 ng kg-1 hr-1) and on plasma concentrations of pancreatic polypeptide (PP) and gastrin. LHRH did not significantly alter pancreatic bicarbonate and protein output in response to secretion and plasma levels of gastrin and PP as measured by radioimmunoassay. The lack of any significant influences of intravenous LHRH on exocrine pancreatic secretion does not exclude an effect of LHRH on pancreatic bicarbonate and enzyme secretion via paracrine delivery.