Becker S, Singer M V, Eysselein V E, Goebell H
Arch Int Pharmacodyn Ther. 1982 May;257(1):138-45.
In 7 conscious dogs with gastric and duodenal Thomas fistulas we studied the effect of an intravenous bolus injection of luteinizing hormone-releasing hormone (LHRH, 100 microgram) on pancreatic bicarbonate and protein secretion stimulated by an intravenous infusion of secretin (500 ng kg-1 hr-1) and on plasma concentrations of pancreatic polypeptide (PP) and gastrin. LHRH did not significantly alter pancreatic bicarbonate and protein output in response to secretion and plasma levels of gastrin and PP as measured by radioimmunoassay. The lack of any significant influences of intravenous LHRH on exocrine pancreatic secretion does not exclude an effect of LHRH on pancreatic bicarbonate and enzyme secretion via paracrine delivery.
在7只具有胃和十二指肠托马斯瘘的清醒犬中，我们研究了静脉推注促黄体生成素释放激素（LHRH，100微克）对静脉输注促胰液素（500纳克/千克/小时）刺激的胰腺碳酸氢盐和蛋白质分泌以及胰腺多肽（PP）和胃泌素血浆浓度的影响。通过放射免疫测定法测量，LHRH并未显著改变胰腺对促胰液素反应时的碳酸氢盐和蛋白质输出以及胃泌素和PP的血浆水平。静脉注射LHRH对胰腺外分泌无任何显著影响，这并不排除LHRH通过旁分泌途径对胰腺碳酸氢盐和酶分泌产生影响。
