Yamagishi F, Iijima F, Iwatsuki K, Komiya I, Yamada T, Chiba S
Arch Int Pharmacodyn Ther. 1985 Mar;274(1):159-65.
Effects of thyrotropin-releasing hormone (TRH) on pancreatic exocrine secretion were investigated in isolated and blood-perfused canine pancreas preparations. During constant intra-arterial infusion of secretin (0.03-0.05 units/min), concentrations of protein and bicarbonate in the pancreatic juice were measured before and after intra-arterial injection of TRH (0.1-10 ng). TRH did not produce any significant changes in the flow rate of pancreatic juice and in the rate of pancreatic blood flow. TRH caused a significant suppression of protein and bicarbonate output in a dose-dependent manner. At 10 ng of TRH, this suppression lasted about 20 min. From these data, it is suggested that TRH acts directly on both acinar and ductular cells of the pancreas and inhibits the secretions of digestive enzymes and bicarbonate.
在离体并经血液灌注的犬胰腺制备物中，研究了促甲状腺激素释放激素（TRH）对胰腺外分泌的影响。在持续动脉内输注促胰液素（0.03 - 0.05单位/分钟）期间，在动脉内注射TRH（0.1 - 10纳克）之前和之后，测量胰液中蛋白质和碳酸氢盐的浓度。TRH对胰液流速和胰腺血流速率未产生任何显著变化。TRH以剂量依赖的方式显著抑制蛋白质和碳酸氢盐的分泌。在注射10纳克TRH时，这种抑制持续约20分钟。根据这些数据，提示TRH直接作用于胰腺的腺泡细胞和导管细胞，并抑制消化酶和碳酸氢盐的分泌。
