Palmer M R, Mathews R, Murphy R C, Hoffer B J
Neurosci Lett. 1980 Jun;18(2):173-80. doi: 10.1016/0304-3940(80)90322-5.
Leukotriene C-1 (LTC-1), a recently characterized potent agonist in bioassays for the slow reacting substance of anaphylaxis (SRS-A), was tested for electrophysiological effects on central neurons. LTC-1 consistently elicited a unique prolonged excitatory action on cerebellar Purkinje (P) cells when administered locally by pressure ejection from a multibarreled micropipette. This excitation could be reversed by subsequent pressure ejection of FPL 55712 (FPL), a SRS-A end-organ antagonist. Prior application of FPL prevented the LTC-1-induced responses altogether. Heat-inactivated LTC-1 had no effect on P cell discharge. These data suggest that LTC-1, as has been recently found with many other peripherally acting neurohormones, may also function to regulate excitability of central neurons.
白三烯C-1（LTC-1）是最近在过敏性慢反应物质（SRS-A）生物测定中被鉴定出的一种强效激动剂，我们测试了它对中枢神经元的电生理效应。当通过多管微量移液器压力喷射局部给药时，LTC-1始终对小脑浦肯野（P）细胞产生独特的延长兴奋性作用。这种兴奋作用可被随后压力喷射的SRS-A终末器官拮抗剂FPL 55712（FPL）逆转。预先应用FPL可完全阻止LTC-1诱导的反应。热灭活的LTC-1对P细胞放电无影响。这些数据表明，正如最近在许多其他外周作用神经激素中发现的那样，LTC-1也可能起到调节中枢神经元兴奋性的作用。
