Palmer M R, Mathews W R, Hoffer B J, Murphy R C
J Pharmacol Exp Ther. 1981 Oct;219(1):91-6.
The biological effects of leukotrienes B4 and D4, two recently characterized products of arachidonic acid metabolism, were studied on the guinea-pig ileum in vitro and on rat cerebellar Purkinje cells in vivo. Leukotriene D4 induced contraction of the ileum and a prolonged excitation of Purkinje cells. Both of these effects were antagonized by the "slow reacting substance" end-organ antagonist, FPL 55712. Leukotriene B4 had no central electrophysiological effects at the doses used and no effects on the guinea-pig ileum at doses below 0.2 microM. Taken together with previous studies, these data suggest that leukotrienes with slow reacting substance activity may modulate the excitability of central neurons as well as peripheral smooth muscle tone.
白三烯B4和D4是最近鉴定出的花生四烯酸代谢产物，我们对其生物学效应进行了研究，采用豚鼠离体回肠和大鼠小脑浦肯野细胞在体实验。白三烯D4可引起回肠收缩以及浦肯野细胞的长时间兴奋。这两种效应均被“慢反应物质”终末器官拮抗剂FPL 55712所拮抗。在所使用的剂量下，白三烯B4没有中枢电生理效应，且在剂量低于0.2微摩尔时对豚鼠回肠没有影响。结合先前的研究，这些数据表明具有慢反应物质活性的白三烯可能会调节中枢神经元的兴奋性以及外周平滑肌张力。
