Stanbridge E J, Der C J, Doersen C J, Nishimi R Y, Peehl D M, Weissman B E, Wilkinson J E
Science. 1982 Jan 15;215(4530):252-9. doi: 10.1126/science.7053574.
Intraspecific human-human cell hybrids provide a stable model system with which to investigate the genetic control of transformed and tumorigenic phenotypes. Using this system it has been shown that these phenotypes are under separate genetic control. Furthermore, the tumorigenic phenotype can be complemented by fusion of different tumorigenic cells, resulting in nontumorigenic hybrids. This system also provides information on the control of differentiated function. Molecular cytogenetic techniques should reveal the nature of the chromosomal control of neoplastic transformation.
种内人-人细胞杂交体提供了一个稳定的模型系统，用以研究转化和致瘤表型的遗传控制。利用该系统已表明，这些表型受不同的遗传控制。此外，不同致瘤细胞的融合可互补致瘤表型，产生非致瘤性杂交体。该系统还提供了有关分化功能控制的信息。分子细胞遗传学技术应能揭示肿瘤转化的染色体控制本质。
