Croce C M, Aden C, Koprowski H
Science. 1975 Dec 19;190(4220):1200-2. doi: 10.1126/science.173020.
Somatic cell hybrids between normal mouse cells and simian virus 40 (SV40)-transformed human cells, which contained a diploid complement of mouse chromosomes and the human chromosome 7 carrying the genome of SV40, were tumorigenic in nude mice. One single copy of human chromosome 7 per hybrid cell appeared to be sufficient for the tumorigenicity of the hybrids.
正常小鼠细胞与猿猴病毒40(SV40)转化的人类细胞之间的体细胞杂种,含有小鼠染色体的二倍体互补物以及携带SV40基因组的人类7号染色体,在裸鼠中具有致瘤性。每个杂种细胞中一条人类7号染色体的单拷贝似乎足以使杂种具有致瘤性。