Mowschenson P M, Rosenberg S, Pallotta J, Silen W
Am J Surg. 1982 Jan;143(1):36-9. doi: 10.1016/0002-9610(82)90126-x.
Heartburn is a frequent and sometimes initial complaint in hyperparathyroidism, and it is often relieved by successful parathyroid surgery. Four of five patients with primary hyperparathyroidism and heartburn obtained relief of symptoms and had an increase in lower esophageal sphincter pressure after successful operative treatment. Four of five volunteers undergoing calcium infusion exhibited a decrease in lower esophageal sphincter pressure after about 2.5 to 3 hours of infusion. Calcium infusion in a treated patient who had an increase in lower esophageal sphincter pressure postoperatively resulted in a transient return of lower esophageal sphincter pressure to preoperative levels.
胃灼热是甲状旁腺功能亢进症中常见且有时是首发的症状，成功的甲状旁腺手术通常可缓解此症状。五名患有原发性甲状旁腺功能亢进症且有胃灼热症状的患者中，有四名在手术治疗成功后症状得到缓解，且食管下括约肌压力增加。五名接受钙输注的志愿者在输注约2.5至3小时后，食管下括约肌压力下降。一名术后食管下括约肌压力增加的接受治疗患者，进行钙输注后，食管下括约肌压力短暂恢复到术前水平。
