痤疮丙酸杆菌诱导小鼠对微小巴贝斯虫产生保护性免疫的遗传控制
Genetic control of Propionibacterium acnes-induced protection of mice against Babesia microti.
作者信息
Wood P R, Clark I A
出版信息
Infect Immun. 1982 Jan;35(1):52-7. doi: 10.1128/iai.35.1.52-57.1982.
Abstract
Using various strains of inbred mice, we found that Propionibacterium acnes-induced protection against the hemoprotozoan parasite Babesia microti was controlled by a dominant gene(s) not linked to the major histocompatibility gene (H2) complex of mice. P. acnes-induced resistance to infection was not merely an amplification of the normal immune response to B. microti, since innate resistance to infection was controlled by different genes. Expression of the nonspecific protection induced by P. acnes was found to be transferable with cells of bone marrow origin, and it did not necessarily accompany the induction of hepatosplenomegaly. The implication of these results for the understanding of the mechanism of P. acnes-induced protection is discussed.
摘要
通过使用各种近交系小鼠，我们发现痤疮丙酸杆菌诱导的针对血液原虫寄生虫微小巴贝斯虫的保护作用由一个不与小鼠主要组织相容性基因（H2）复合体连锁的显性基因控制。痤疮丙酸杆菌诱导的抗感染能力并非仅仅是对微小巴贝斯虫正常免疫反应的增强，因为先天性抗感染能力由不同基因控制。发现痤疮丙酸杆菌诱导的非特异性保护作用可随骨髓来源的细胞转移，并且它不一定伴随着肝脾肿大的诱导。讨论了这些结果对于理解痤疮丙酸杆菌诱导保护机制的意义。
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