Vadas M A
J Immunol. 1982 Feb;128(2):691-5.
A heterogeneity in the capacity of strains of mice to mount eosinophilia is described. BALB/c and C3H are eosinophil high responder strains (EO-HR) and CBA and A/J are eosinophil low responder strains (EO-LR), judged by the response of blood eosinophils to Ascaris suum, and the response of blood, bone marrow, and spleen eosinophils to keyhole limpet hemocyanin given 2 days after 150 mg/kg cyclophosphamide. Some of the gene(s) for high responsiveness appear to be dominant because (EO-HR X EO-LR)F1 mice were intermediate to high responders. This gene is expressed in bone marrow-derived cells because radiation chimeras of the type EO-HR leads to F1 were high responders and EO-LR leads to F1 were low responders. This description of a genetic control of eosinophilia in mice may be useful in understanding the role of this cell in parasite immunity and allergy.
本文描述了小鼠品系引发嗜酸性粒细胞增多能力的异质性。通过血液嗜酸性粒细胞对猪蛔虫的反应，以及血液、骨髓和脾脏嗜酸性粒细胞对150mg/kg环磷酰胺注射2天后给予的匙孔血蓝蛋白的反应来判断，BALB/c和C3H是嗜酸性粒细胞高反应品系（EO-HR），而CBA和A/J是嗜酸性粒细胞低反应品系（EO-LR）。一些高反应性基因似乎是显性的，因为（EO-HR×EO-LR）F1小鼠的反应介于高反应者和中等反应者之间。该基因在骨髓来源的细胞中表达，因为EO-HR→F1类型的辐射嵌合体是高反应者，而EO-LR→F1类型的辐射嵌合体是低反应者。对小鼠嗜酸性粒细胞增多的遗传控制的这种描述可能有助于理解这种细胞在寄生虫免疫和过敏中的作用。
