Linn S, Schoenbaum S C, Monson R R, Rosner B, Stubblefield P G, Ryan K J
N Engl J Med. 1982 Jan 21;306(3):141-5. doi: 10.1056/NEJM198201213060304.
We analyzed interview and medical-record data of 12,205 non-diabetic, non-asthmatic women to evaluate the relation between coffee consumption and adverse outcomes of pregnancy. Low birth weight and short gestation occurred more often among offspring of women who drank four or more cups of coffee a day and more often among the offspring of smokers. After controlling for smoking, other habits, demographic characteristics, and medical history by standardization and logistic regression, we found no relation between low birth weight or short gestation and heavy coffee consumption. Furthermore, there was no excess of malformations among coffee drinkers. These negative results suggest that coffee consumption has a minimal effect, if any, on the outcome of pregnancy.
我们分析了12205名非糖尿病、非哮喘女性的访谈和病历数据，以评估咖啡摄入量与妊娠不良结局之间的关系。低出生体重和早产在每天饮用四杯或更多咖啡的女性后代中更为常见，在吸烟者的后代中也更为常见。通过标准化和逻辑回归控制吸烟、其他习惯、人口统计学特征和病史后，我们发现低出生体重或早产与大量饮用咖啡之间没有关系。此外，喝咖啡的女性中畸形儿并无增多。这些阴性结果表明，咖啡摄入对妊娠结局即便有影响，也是极小的。
