Sugarbaker P H, Barofsky I, Rosenberg S A, Gianola F J
Surgery. 1982 Jan;91(1):17-23.
Twenty-six patients with soft tissue sarcoma who participated in a randomized controlled clinical trial were studied to compare the impact of treatments on quality of life. Patients were treated with amputation plus chemotherapy or with limb-sparing surgery plus radiation therapy plus chemotherapy. After completion of treatments, when the patients' physical status had stabilized, a "Quality of Life Assessment" was administered. It consisted of the Psychosocial Adjustment to Illness Scale, the Sickness Impact Profile, the Barthel Function Scale, the Katz Activities of Daily Living Scale, nd an economic assessment. In addition, clinical assessments of mobility, pain, sexual relationships, and treatment trauma were obtained. Analysis of these assessments indicated that our hypothesis that limb-sparing surgery plus irradiation would provide improved quality of life when compared to amputation was not substantiated.
对26名参与随机对照临床试验的软组织肉瘤患者进行了研究，以比较不同治疗方法对生活质量的影响。患者分别接受截肢加化疗或保肢手术加放疗加化疗。治疗结束后，当患者身体状况稳定时，进行了一次“生活质量评估”。评估内容包括疾病心理社会适应量表、疾病影响概况、巴氏功能量表、卡茨日常生活活动量表以及经济评估。此外，还获得了关于活动能力、疼痛、性关系和治疗创伤的临床评估。对这些评估的分析表明，我们的假设——与截肢相比，保肢手术加放疗能改善生活质量——没有得到证实。
