Kemeny M M, Sugarbaker P H, Smith T J, Edwards B K, Shawker T, Vermess M, Jones A E
Ann Surg. 1982 Feb;195(2):163-7. doi: 10.1097/00000658-198202000-00007.
A prospective study of the ability of laboratory tests and liver imaging tests to detect hepatic metastases was performed. Eighty patients at risk for hepatic metastases but without clinical evidence of disease were tested with 13 laboratory tests and three liver imaging tests. No single laboratory test had greater than 65% accuracy in the detection of hepatic lesions. No combination of the laboratory tests increased this accuracy. If the laboratory tests were used with one of the liver imaging tests, the accuracy was improved in some combinations to 76%. The CEA assay when analyzed in patients with colorectal primaries had an accuracy of 79%. The results show that the laboratory tests alone are not sufficiently accurate to detect liver metastases. Additional accuracy can be obtained by the combined use of a single liver imaging test and selected laboratory tests. Use of all the liver imaging tests and laboratory tests lowers the accuracy and increases the expense and thus is unnecessary.
开展了一项关于实验室检查和肝脏影像学检查检测肝转移能力的前瞻性研究。对80例有肝转移风险但无疾病临床证据的患者进行了13项实验室检查和3项肝脏影像学检查。没有任何一项实验室检查在检测肝病变方面的准确率超过65%。实验室检查的任何组合都没有提高这一准确率。如果将实验室检查与一项肝脏影像学检查联合使用，某些组合的准确率可提高到76%。对原发性结直肠癌患者进行癌胚抗原（CEA）检测时，准确率为79%。结果表明，仅靠实验室检查检测肝转移的准确性不足。通过联合使用一项肝脏影像学检查和选定的实验室检查可提高准确率。使用所有肝脏影像学检查和实验室检查会降低准确率，增加费用，因此并无必要。
