Hische E A, van der Helm H J, van Walbeek H K
Clin Chem. 1982 Feb;28(2):354-5.
Having determined immunoglobulin G (IgG) and albumin concentrations in 1100 cerebrospinal fluid and serum samples, we calculated the IgG index. Likelihood ratios for multiple sclerosis were calculated by using a training set consisting of 100 patients with definite multiple sclerosis and one consisting of 97 patients suffering from diseases from which multiple sclerosis must be differentiated. Predictive values for multiple sclerosis, given different values for the IgG index, are given in a graphical representation of Bayes' theorem. We conclude that this approach increases the diagnostic usefulness of the IgG index for the diagnosis of multiple sclerosis.
在测定了1100份脑脊液和血清样本中的免疫球蛋白G（IgG）和白蛋白浓度后，我们计算了IgG指数。通过使用由100例确诊为多发性硬化症的患者组成的训练集以及由97例患有必须与多发性硬化症相鉴别的疾病的患者组成的训练集，计算了多发性硬化症的似然比。在贝叶斯定理的图形表示中给出了给定不同IgG指数值时多发性硬化症的预测值。我们得出结论，这种方法提高了IgG指数在多发性硬化症诊断中的诊断效用。
