Wells J D, Hansebout R R
Surg Neurol. 1978 Sep;10(3):200-4.
A series of controlled animal experiments comparing the effects of one, four, and 18 hours of local hypothermia at 6 degrees C begun four hours after compression lesions to the thoracic cord in dogs is reported. Four hours of local cooling delivered by a small silastic epidural heat exchanger, without durotomy or tissue perfusion, is shown to give greater functional benefit than cooling for one hour or 18 hours. Experimental design, pathophysiological implications, and clinical relevance are discussed.
报告了一系列对照动物实验，该实验比较了在犬胸段脊髓压迫性损伤4小时后开始的6℃局部低温1小时、4小时和18小时的效果。通过小型硅橡胶硬膜外热交换器进行4小时局部降温，不进行硬脊膜切开或组织灌注，结果显示其功能益处大于1小时或18小时的降温。讨论了实验设计、病理生理学意义和临床相关性。
