Casey M L, Hurd E R, Gilliam J N, MacDonald P C, Johnston J M
Immunology. 1982 Jan;45(1):23-6.
Prostaglandins, or related compounds, as well as estrogen and androgen are believed to be involved in the processes that lead to the development of murine lupus erythematosus (LE) in NZB/NZW F1 hybrid mice. In this investigation we measured NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) activity in kidney tissue of male and female NZB/NZW F1 hybrid mice and in kidney tissue of male and female mice of other strains. In each case the specific activity of PGDH was significantly greater in kidney tissue of male than in kidney tissue of female mice. However, the specific activities of PGDH in kidney tissues of males of various strains of mice were similar, and the specific activities of PGDH in kidney tissues of females of various strains-including the NZB/NZW F1 hybrid- were similar. Thus, while the lower activity of PGDH in kidney tissues of the female may be important in the pathogenesis of LE, the lower activity of this enzyme is not unique to the kidney of the female NZB/NZW F1 hybrid mouse.
前列腺素或相关化合物，以及雌激素和雄激素被认为参与了导致NZB/NZW F1杂交小鼠发生鼠类红斑狼疮（LE）的过程。在本研究中，我们测量了雄性和雌性NZB/NZW F1杂交小鼠肾组织以及其他品系雄性和雌性小鼠肾组织中依赖NAD+的15-羟基前列腺素脱氢酶（PGDH）的活性。在每种情况下，雄性小鼠肾组织中PGDH的比活性显著高于雌性小鼠肾组织中的比活性。然而，不同品系雄性小鼠肾组织中PGDH的比活性相似，包括NZB/NZW F1杂交小鼠在内的不同品系雌性小鼠肾组织中PGDH的比活性也相似。因此，虽然雌性肾组织中PGDH活性较低可能在LE的发病机制中起重要作用，但该酶活性较低并非雌性NZB/NZW F1杂交小鼠肾脏所特有。
