Casey M L, Johnston J M, MacDonald P C
J Reprod Fertil. 1981 Sep;63(1):263-6. doi: 10.1530/jrf.0.0630263.
The specific activity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) was significantly greater (P less than 0.005) in human kidney tissue obtained from male abortuses aged 10--16 weeks after conception than in female abortuses of the same gestational age and in younger male and female abortuses. There was a significant correlation (r = 0.93, P less than 0.001) between the specific activity of PGDH in fetal kidney and testicular tissues obtained from human abortuses of 10--26 weeks gestational age. These results suggest a role for testosterone in the regulation of PGDH activity in the fetal kidney.
从妊娠10至16周的男性流产胎儿获取的人肾组织中，NAD+依赖的15-羟基前列腺素脱氢酶（PGDH）的比活性显著更高（P<0.005），高于相同胎龄的女性流产胎儿以及更年幼的男性和女性流产胎儿。在胎龄为10至26周的人流产胎儿的胎儿肾和睾丸组织中，PGDH的比活性之间存在显著相关性（r = 0.93，P<0.001）。这些结果表明睾酮在调节胎儿肾中PGDH活性方面发挥作用。
