Sayle B A, Helmer R E, Birdsong B A, Balachandran S, Gardner F H
J Nucl Med. 1982 Feb;23(2):121-5.
Twenty-nine patients with aplastic anemia and 11 patients with myelofibrosis were evaluated with indium-111 chloride bone-marrow imaging, ferrokinetics, and bone-marrow core biopsies. There was good correlation between the erythrocyte cellularity of the marrow and the In-111 bone-marrow scan grades in most patients. In some, the overall scan grade tended to underestimate the erythroid elements because the core biopsy had been taken from the area of the greatest radionuclide concentration on the scan. In patients with aplastic anemia, there was good correlation between the plasma iron clearance t1/2 and the scan grade. Less agreement was found in the comparison between the Fe-59 sacral and organ counts and the red-cell iron utilization. In patients with myelofibrosis, there was poor correlation between the surface counts over the sacrum and the red-cell iron utilization. Plasma iron clearances were abnormally short and were unrelated to the transferrin saturation levels. Eighteen patients were studied several times to evaluate their responses to steroid therapy. In all, there was good correlation between the bone-marrow imaging, the erythrocyte cellularity, ferrokinetics, and the patient's response to therapy. Indium-111 bone-marrow imaging is useful both in evaluating marrow erythroid activity and in following the response to therapy in patients with these diseases.
对29例再生障碍性贫血患者和11例骨髓纤维化患者进行了氯化铟-111骨髓显像、铁动力学及骨髓活检评估。大多数患者骨髓红细胞细胞密度与铟-111骨髓扫描分级之间具有良好的相关性。在一些患者中，由于活检取自扫描时放射性核素浓度最高的区域，总体扫描分级往往低估了红系成分。再生障碍性贫血患者血浆铁清除半衰期（t1/2）与扫描分级之间具有良好的相关性。在比较铁-59骶骨和器官计数与红细胞铁利用率时，发现一致性较差。骨髓纤维化患者骶骨表面计数与红细胞铁利用率之间相关性较差。血浆铁清除异常缩短，且与转铁蛋白饱和度水平无关。对18例患者进行了多次研究以评估其对类固醇治疗的反应。总体而言，骨髓显像、红细胞细胞密度、铁动力学与患者对治疗的反应之间具有良好的相关性。铟-111骨髓显像对于评估这些疾病患者的骨髓红系活性及随访治疗反应均有用。
