Najean Y, Le Danvic M, Le Mercier N, Pecking A, Colonna P, Rain J D
J Nucl Med. 1980 Mar;21(3):213-8.
Tc-99m colloid and In-111 transferrin were used in a semiquantitative scintigraphic study of bone-marrow activity in 76 patients with aplastic anemia, the majority of which were severe cases. The results are compared with other known prognostic parameters and with a predictive index formulated from a prior multi-parametric analysis performed in 352 cases. In 47 cases parallel abnormality of Tc and In uptakes was noted and was well correlated with other prognostic factors. Indium uptake is apparently a good indicator of the severity of aplasia; extension of active erythroid tissue, demonstrated with this method, is correlated with prognosis. In nine cases, excessive In uptake is explained by dyserythropoiesis associated with granulo- and thrombocytopenia (Fanconi's anemia in most cases). In 20 of our patients, TcSC uptake was excessive compared with that of In and with other prognostic factors. Statistically, this phenomenon carries an unfavorable prognosis but its physiological meaning remains to be defined.
锝-99m胶体和铟-111转铁蛋白被用于76例再生障碍性贫血患者骨髓活性的半定量闪烁扫描研究，其中大多数为重症病例。将结果与其他已知的预后参数以及由之前对352例病例进行的多参数分析得出的预测指数进行比较。在47例病例中，观察到锝和铟摄取的平行异常，且与其他预后因素密切相关。铟摄取显然是再生障碍严重程度的良好指标；用此方法显示的活跃红系组织扩展与预后相关。在9例病例中，铟摄取过多是由与粒细胞减少和血小板减少相关的红细胞生成异常（大多数病例为范可尼贫血）所致。在我们的20例患者中，与铟摄取及其他预后因素相比，硫化锝摄取过多。从统计学上看，这种现象预后不良，但其生理意义仍有待确定。
