实验性丝虫病中形成的循环免疫复合物对黏附及细胞毒性的抑制作用

Inhibition of adherence and cytotoxicity by circulating immune complexes formed in experimental filariasis.

作者信息

Karavodin L M, Ash L R

出版信息

Parasite Immunol. 1982 Jan;4(1):1-12. doi: 10.1111/j.1365-3024.1982.tb00415.x.

DOI:10.1111/j.1365-3024.1982.tb00415.x

Abstract

Peritoneal exudate cells (PEC) from normal jirds (Meriones unguiculatus) showed adherence of Brugia pahangi microfilariae, and subsequent cytotoxicity in the presence of antimicrofilarial antisera. Heat inactivation of the antisera diminished both adherence and cytotoxicity, but readdition of fresh normal jird sera only partially restored the reactions. Macrophages were the predominant adherent cell type. Circulating immune complexes precipitated with polyethylene glycol (PEG) from the sera of jirds with an 8-month infection inhibited both of these reactions. Complement consumption by the precipitated complexes was found not to be the cause of inhibition. Blocking of adherence and cytotoxicity by circulating immune complexes may be preventing the trapping of microfilariae in vivo, and may play a role in the persistence of microfilaraemia in the jird.

摘要

来自正常沙鼠（长爪沙鼠）的腹腔渗出细胞（PEC）显示出对彭亨布鲁线虫微丝蚴的黏附，以及在抗微丝蚴抗血清存在下的后续细胞毒性。抗血清的热灭活降低了黏附和细胞毒性，但重新添加新鲜的正常沙鼠血清仅部分恢复了反应。巨噬细胞是主要的黏附细胞类型。用聚乙二醇（PEG）从感染8个月的沙鼠血清中沉淀出的循环免疫复合物抑制了这两种反应。发现沉淀复合物的补体消耗不是抑制的原因。循环免疫复合物对黏附和细胞毒性的阻断可能会阻止微丝蚴在体内的捕获，并可能在沙鼠微丝蚴血症的持续存在中起作用。