Bartlett A, Turk J, Ngu J, Mackenzie C D, Fuglsang H
Trans R Soc Trop Med Hyg. 1978;72(4):372-7. doi: 10.1016/0035-9203(78)90130-x.
Soluble antigen preparations were made from Onchocerca volvulus adults recovered from subcutaneous nodules, and from Necator americanus third-stage larvae. Intradermal skin tests were carried out on a total of 100 individuals clinically classified as having either the generalized form of onchocerciasis (86 cases, or the localized sowda form (14 cases). 91 of the people studied produced immediate reactions to the onchocercal antigen, but only those with sowda showed delayed reactions, though one person with generalized disease showed a doubtful delayed reaction. Reactions to N. americanus antigen, both immediate and delayed, were seen in both forms of the disease. The lack of delayed skin reaction in the generalized form of onchocerciasis is discussed, and a comparison is made with other diseases. Preliminary evidence for the existence of a true spectrum of clinical and immunological forms of onchocerciasis is suggested by one case in this study.
可溶性抗原制剂是由从皮下结节中取出的盘尾丝虫成虫以及美洲板口线虫三期幼虫制成的。对总共100名临床上被分类为患有盘尾丝虫病全身性形式（86例）或局限性苏丹型（14例）的个体进行了皮内皮肤试验。91名研究对象对盘尾丝虫抗原产生了即时反应，但只有患有苏丹型的人出现了延迟反应，尽管有一名全身性疾病患者出现了可疑的延迟反应。在两种疾病形式中均观察到对美洲板口线虫抗原的即时和延迟反应。文中讨论了盘尾丝虫病全身性形式中缺乏延迟皮肤反应的情况，并与其他疾病进行了比较。本研究中的一个病例提示了盘尾丝虫病存在真正的临床和免疫形式谱的初步证据。
