Marshall V, Ross B, Bishop M, Morris P
Transplantation. 1978 Nov;26(5):315-8. doi: 10.1097/00007890-197811000-00010.
An isolated perfused rat kidney has been used to determine the response to prolonged warm ischaemia and to examine renal preservation procedures. All measurements of function declined to near zero after 90 min of warm ischaemia. Measurement of total sodium reabsorption (TNa) was the most sensitive indicator of renal damage. Inosine was without effect on subsequent renal function after 60 or 90 min of warm ischaemia, or after 24 hr of cold ischaemia. Surface cooling or hypertonic citrate solution, in the cold or at 37 degrees C, significantly improved renal function, and their use in clinical renal preservation rather than that of inosine was supported by the present results.
离体灌注大鼠肾脏已被用于确定对长时间热缺血的反应，并研究肾脏保存程序。热缺血90分钟后，所有功能测量值均降至接近零。总钠重吸收（TNa）的测量是肾脏损伤最敏感的指标。在热缺血60或90分钟后，或冷缺血24小时后，肌苷对随后的肾功能没有影响。表面冷却或高渗柠檬酸盐溶液，无论是在低温还是37摄氏度下，都能显著改善肾功能，本研究结果支持将其用于临床肾脏保存而非肌苷。
