Yü T F, Berger L
Am J Med. 1982 Jan;72(1):95-100. doi: 10.1016/0002-9343(82)90593-9.
Inulin clearance was measured in 624 patients with gout, and para-aminohippuric acid (PAH) clearance in 359; Group I consisted of 397 patients with uncomplicated gout; Group II, 191 patients with hypertension and/or ischemic heart disease; and Group III, 36 patients with chronic renal disease. Mean inulin clearance was normal in Group I, slightly depressed in Group II and more markedly decreased in Group III. There was some reduction in PAH clearance in all groups, but not in the very young patients with no complications. A disproportionate reduction in PAH clearance was noted in Groups II and III, particularly in the older patients with longer duration of gout. Uncomplicated gout, except in rare cases of fulminating gout, does not lead to decreased renal hemodynamics. An increased incidence of tophi correlates with decreased renal function, but incidence of renal calculi does not. Renal insufficiency when seen in patients with gout usually correlates with coexistence of hypertension, ischemic heart disease, or primary preexistent renal insufficiency.
对624例痛风患者进行了菊粉清除率测定，对359例患者进行了对氨基马尿酸（PAH）清除率测定；第一组由397例单纯性痛风患者组成；第二组，191例患有高血压和/或缺血性心脏病的患者；第三组，36例患有慢性肾病的患者。第一组的平均菊粉清除率正常，第二组略有降低，第三组则明显下降。所有组的PAH清除率均有一定程度的降低，但无并发症的非常年轻的患者除外。第二组和第三组中PAH清除率不成比例地降低，尤其是痛风病程较长的老年患者。除罕见的暴发性痛风病例外，单纯性痛风不会导致肾血流动力学下降。痛风石发病率的增加与肾功能下降相关，但肾结石的发病率则不然。痛风患者出现肾功能不全通常与高血压、缺血性心脏病或原发性既往存在的肾功能不全并存有关。
