丙氨酸对神经胶质瘤和脑膜瘤中丙酮酸激酶的抑制作用。神经胶质瘤手术中的一种诊断工具？
Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas?
作者信息
van Veelen C W, Staal G E, Verbiest H, Vlug A M
出版信息
Lancet. 1977 Aug 20;2(8034):384-5. doi: 10.1016/s0140-6736(77)90308-7.
PMID:70592
Abstract
In gliomas a shift was found in the composition of enzymes, manifested by abnormal inhibition of pyruvate kinase by alanine. This study demonstrates the appearance of the MII-type isoenzyme in various gliomas. This MII type is also found in meningiomas but not in normal brain tissue. The method of enzyme examination described may be valuable as a diagnostic aid in the surgery of gliomas.
摘要
在神经胶质瘤中，发现酶的组成发生了变化，表现为丙氨酸对丙酮酸激酶的异常抑制。本研究证明了MII型同工酶在各种神经胶质瘤中的出现。在脑膜瘤中也发现了这种MII型同工酶，但在正常脑组织中未发现。所描述的酶检测方法作为神经胶质瘤手术中的诊断辅助手段可能具有价值。
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