烷基汞化合物与亚硒酸钠的相互作用。II. 单独及与亚硒酸钠联合给予大鼠氯化甲基汞后的代谢情况
Interaction of alkylmercuric compounds with sodium selenite. II. Metabolism of methylmercuric chloride administered alone and in combination with sodium selenite in rats.
作者信息
Brzeźnicka E A, Chmielnicka J
出版信息
Environ Health Perspect. 1985 May;60:411-21. doi: 10.1289/ehp.60-1568548.
Abstract
Repeated doses of sodium selenite (Se) were administered to rats receiving repeated (IV or PO) doses of 0.25 or 2.5 mg Hg/kg methylmercuric chloride (Me2(203)Hg). Se (0.5 mg/kg) was observed to alter the distribution of Me203Hg among tissues as well as among subcellular fractions of kidneys and liver. An excess of selenium resulted in a twofold decrease in the mercury content of kidneys and a similar increase in the mercury content of brain.
摘要
给接受重复（静脉注射或口服）剂量为0.25或2.5毫克汞/千克甲基氯化汞（Me2(203)Hg）的大鼠重复注射亚硒酸钠（Se）。观察到硒（0.5毫克/千克）会改变Me203Hg在组织以及肾脏和肝脏亚细胞部分中的分布。过量的硒导致肾脏汞含量降低两倍，而大脑汞含量有类似程度的增加。
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本文引用的文献
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Time-dependent accumulation of inorganic mercury in subcellular fractions of kidney, liver, and brain of rats exposed to methylmercury.暴露于甲基汞的大鼠肾脏、肝脏和大脑亚细胞组分中无机汞的时间依赖性积累。
Arch Toxicol. 1980 Apr;44(4):231-41. doi: 10.1007/BF00278031.
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