“年轻”与“年老”人类红细胞的冷冻断裂表征

Freeze-fracture characterization of 'young' and 'old' human erythrocytes.

作者信息

Fischbeck K H, Bonilla E, Schotland D L

出版信息

Biochim Biophys Acta. 1982 Feb 23;685(2):207-10. doi: 10.1016/0005-2736(82)90100-6.

Abstract

While 'young' and 'old' erythrocytes separated by density show differences in various biochemical properties, the membrane ultrastructure as demonstrated by freeze-fracture remains unchanged. This implies that although superficial membrane components may be affected by aging, and whole segments of membrane may be lost, the structural relationship between integral protein and lipid in the remaining membrane is not altered.

摘要

虽然通过密度分离的“年轻”和“年老”红细胞在各种生化特性上存在差异，但冷冻断裂显示的膜超微结构保持不变。这意味着，尽管表面膜成分可能受衰老影响，且膜的整个片段可能丢失，但剩余膜中整合蛋白与脂质之间的结构关系并未改变。