Yokoyama M, Tomoi M, Taguchi T, Nakano T, Asai H, Ono T, Kitamura Y
Am J Pathol. 1985 Jun;119(3):367-75.
Antral ulcers develop spontaneously in (WB X C57BL/6)F1-W/Wv mice. Most W/Wv mice with severe ulcers die within 3 months after birth. When healthy-looking W/Wv mice were selected at 4 months of age, 80-90% of them were free from the ulcer. Even if the ulcer was present, it was small. The authors compared the susceptibility of such healthy-looking W/Wv mice to ulcerogenic treatments with that of the congenic +/+ mice. Stress caused development of fundic erosions in both W/Wv and +/+ mice. The susceptibility of the W/Wv mice to either cold or water-immersed stress was not higher than that of the +/+ mice. Topical administration of aspirin produced erosions in both fundus and antrum. The susceptibility of W/Wv mice to aspirin was comparable to that of the +/+ mice in either the starved or the fed condition. Subcutaneous injection of indomethacin produced both fundic erosions and antral ulcers in the starved condition, but it produced only antral ulcers in the conventionally fed condition. The susceptibility of the starved W/Wv mice to indomethacin was not higher than that of the starved +/+ mice. In contrast, the fed W/Wv mice were significantly more susceptible to indomethacin than the fed +/+ mice. A considerable proportion of the fed W/Wv mice died of blood loss from the ulcer within 24 hours. The size of the ulcer of the W/Wv mice was significantly larger than that of the +/+ mice. Both genetic and feeding conditions seem to determine the susceptibility to indomethacin.
（WB×C57BL/6）F1-W/Wv小鼠会自发形成胃窦溃疡。大多数患有严重溃疡的W/Wv小鼠在出生后3个月内死亡。当在4个月大时挑选外观健康的W/Wv小鼠时，其中80%-90%没有溃疡。即使有溃疡，也很小。作者将这种外观健康的W/Wv小鼠与同基因的+/+小鼠对致溃疡治疗的易感性进行了比较。应激会导致W/Wv和+/+小鼠的胃底糜烂。W/Wv小鼠对寒冷或水浸应激的易感性不高于+/+小鼠。局部应用阿司匹林会导致胃底和胃窦糜烂。在饥饿或喂食状态下，W/Wv小鼠对阿司匹林的易感性与+/+小鼠相当。皮下注射吲哚美辛在饥饿状态下会导致胃底糜烂和胃窦溃疡，但在常规喂食状态下只会导致胃窦溃疡。饥饿的W/Wv小鼠对吲哚美辛的易感性不高于饥饿的+/+小鼠。相比之下，喂食的W/Wv小鼠比喂食的+/+小鼠对吲哚美辛更敏感。相当一部分喂食的W/Wv小鼠在24小时内因溃疡失血而死亡。W/Wv小鼠的溃疡大小明显大于+/+小鼠。遗传和喂养条件似乎都决定了对吲哚美辛的易感性。
