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肿瘤启动子刺激的梅森-辉瑞猴病毒合成

Tumor promoter-stimulated synthesis of Mason-:Pfizer monkey virus.

作者信息

Wunderlich V, Baumbach L, Sydow G

出版信息

J Cancer Res Clin Oncol. 1982;102(3):271-5. doi: 10.1007/BF00411347.

DOI:10.1007/BF00411347
PMID:7061574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12253333/
Abstract

The tumor promoter 12-0-tetradecanoyl-phorbol-14-acetate (TPA) increases by severalfold the synthesis of Mason-Pfizer monkey virus (MPMV), a type D retrovirus, when the virus is growing in human embryo kidney (HEK) cells. The effect is transient and paralleled by a striking morphological alteration of the cells. The optimal TPA concentration for stimulation is 5 ng. ml-1. Contrary to infected HEK cells, TPA induces at similar concentrations neither stimulation of MPMV synthesis nor altered morphology in persistently MPMV-infected cells of the continuous human tumor cell line A 204.

摘要

肿瘤启动子十四烷酰佛波醇乙酯（TPA）在梅森-辉瑞猴病毒（MPMV，一种D型逆转录病毒）于人类胚胎肾（HEK）细胞中生长时，可使其合成增加数倍。这种效应是短暂的，并且伴随着细胞显著的形态改变。刺激的最佳TPA浓度为5 ng·ml-1。与受感染的HEK细胞相反，TPA在相似浓度下既不诱导持续感染MPMV的人源连续肿瘤细胞系A 204中MPMV合成的刺激，也不引起形态改变。

相似文献

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Tumor promoter-stimulated synthesis of Mason-:Pfizer monkey virus.肿瘤启动子刺激的梅森-辉瑞猴病毒合成
J Cancer Res Clin Oncol. 1982;102(3):271-5. doi: 10.1007/BF00411347.
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Interaction of viruses with tumor promotors.病毒与肿瘤促进剂的相互作用。
Rev Physiol Biochem Pharmacol. 1984;101:111-59. doi: 10.1007/BFb0027695.

本文引用的文献

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Reversible inhibition of cell differentiation by phorbol esters as a possible mechanism of the promotion step in chemical carcinogenesis.佛波酯对细胞分化的可逆性抑制作用可能是化学致癌促进阶段的一种机制。
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[A fast and simple micromethod for estimating proteins].一种快速简便的蛋白质微量测定方法
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Characterization of Mason-Pfizer virus induced cell transformation in vitro.体外梅森-辉瑞病毒诱导细胞转化的特征分析。
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Interactions between adenovirus, a tumor promoter, and chemical carcinogens in transformation of rat embryo cell cultures.肿瘤启动子腺病毒与化学致癌物在大鼠胚胎细胞培养物转化中的相互作用。
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Tumour promoter TPA enhances transformation of human leukocytes by Epstein-Barr virus.肿瘤促进剂佛波酯增强爱泼斯坦-巴尔病毒对人白细胞的转化作用。
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Tumor initiators and promoters in the induction of Epstein-Barr virus.诱导爱泼斯坦-巴尔病毒过程中的肿瘤引发剂和促进剂。
Proc Natl Acad Sci U S A. 1979 Feb;76(2):782-5. doi: 10.1073/pnas.76.2.782.

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