肿瘤启动子刺激的梅森-辉瑞猴病毒合成

Tumor promoter-stimulated synthesis of Mason-:Pfizer monkey virus.

作者信息

Wunderlich V, Baumbach L, Sydow G

出版信息

J Cancer Res Clin Oncol. 1982;102(3):271-5. doi: 10.1007/BF00411347.

DOI:10.1007/BF00411347

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12253333/

Abstract

The tumor promoter 12-0-tetradecanoyl-phorbol-14-acetate (TPA) increases by severalfold the synthesis of Mason-Pfizer monkey virus (MPMV), a type D retrovirus, when the virus is growing in human embryo kidney (HEK) cells. The effect is transient and paralleled by a striking morphological alteration of the cells. The optimal TPA concentration for stimulation is 5 ng. ml-1. Contrary to infected HEK cells, TPA induces at similar concentrations neither stimulation of MPMV synthesis nor altered morphology in persistently MPMV-infected cells of the continuous human tumor cell line A 204.

摘要

肿瘤启动子十四烷酰佛波醇乙酯（TPA）在梅森-辉瑞猴病毒（MPMV，一种D型逆转录病毒）于人类胚胎肾（HEK）细胞中生长时，可使其合成增加数倍。这种效应是短暂的，并且伴随着细胞显著的形态改变。刺激的最佳TPA浓度为5 ng·ml-1。与受感染的HEK细胞相反，TPA在相似浓度下既不诱导持续感染MPMV的人源连续肿瘤细胞系A 204中MPMV合成的刺激，也不引起形态改变。

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