Sengelaub D R, Finlay B L
J Comp Neurol. 1982 Feb 1;204(4):311-7. doi: 10.1002/cne.902040402.
Degenerating cells may be observed with light microscopy in the hamster retinal ganglion cell layer during early postnatal development. On the first postnatal day, degenerating cell profiles were found at a rate of 2.7 per 1,000 live cells. This rate increased to a peak of 14.7 degenerating cells per 1,000 live on postnatal day 5 and then slowed to 4.2 per 1,000 live by postnatal day 10. These rates of cell death correspond to a 49% reduction in cell number in the ganglion cell layer. Examination of the spatial pattern of cell death revealed that although on visual inspection degenerating cells appear to occur in clumps, statistical analysis demonstrated a random distribution within renal areas. Across the retina, cell death rates were higher in peripheral retina than in central retina. The timing and pattern observed correspond well with that of cell degeneration observed in the superficial layers of the superior colliculus, the major target of the retinal projection.
在出生后早期发育阶段，用光学显微镜可观察到仓鼠视网膜神经节细胞层中的退化细胞。在出生后的第一天，每1000个活细胞中发现退化细胞轮廓的比例为2.7个。这个比例在出生后第5天增加到每1000个活细胞中有14.7个退化细胞的峰值，然后在出生后第10天减缓到每1000个活细胞中有4.2个。这些细胞死亡率相当于神经节细胞层中细胞数量减少了49%。对细胞死亡空间模式的检查表明，尽管肉眼观察时退化细胞似乎成簇出现，但统计分析显示在视网膜区域内是随机分布的。在整个视网膜中，周边视网膜的细胞死亡率高于中央视网膜。观察到的时间和模式与视网膜投射的主要靶标上丘浅层中观察到的细胞退化情况非常吻合。
