Ross R J, Thompson J S, Kim K, Bailey R A
Radiology. 1982 Apr;143(1):195-205. doi: 10.1148/radiology.143.1.7063727.
In vivo clinical evaluations of human mammary tissue, including normal, dysplastic, and neoplastic breasts, were initiated using the FONAR method of nuclear magnetic resonance (NMR) imaging. Spin-lattice relaxation times (T1) were determined and correlated with other diagnostic modalities including mammography, xeroradiography, and sonography. Normal breasts and breasts with extensive fatty replacement were found to have the lowest T1 values, whereas T1 values of malignant tissue were elevated. T1 values for mammary dysplasia extended over a wide range, and NMR images exhibited lower proton density than normal tissue. In several patients with severely dysplastic breasts, T1 values overlapped those from patients with documented breast neoplasms. Markedly elevated T1 values were obtained from fluid-filled cysts that were well beyond the range of malignancy.
利用FONAR核磁共振（NMR）成像方法，对包括正常、发育异常和肿瘤性乳房在内的人体乳腺组织进行了体内临床评估。测定了自旋晶格弛豫时间（T1），并将其与其他诊断方法（包括乳房X线摄影、干板X线摄影和超声检查）进行关联。发现正常乳房和脂肪广泛替代的乳房T1值最低，而恶性组织的T1值升高。乳腺发育异常的T1值范围很广，NMR图像显示质子密度低于正常组织。在几名乳腺严重发育异常的患者中，T1值与有记录的乳腺肿瘤患者的T1值重叠。从充满液体的囊肿中获得的T1值明显升高，远远超出了恶性肿瘤的范围。
