[Effect of antibodies to different brain-specific proteins on the formation of motor reactions in the rat].

On Skinner and darkness passive avoidance models, a study was made of the formation of purposive behaviour in rats following an artificial change in the metabolism of brain-specific proteins S100, CP-25 and S60-200 (the two latter isolated for the first time) by means of intraventricular injection of corresponding antibodies. (Administration of non-immune antibodies was used as control.) None of them exerted any influence on motor activity, use of water and food or on speed of learning. Change in the metabolism of CP-25 did not affect elaboration of habits. Action on S100 and S60-200 produced a stage by stage change of habit formation typical of each of them. An assumption was made of connection of S100 with the apparatus of afferent synthesis and of connection of S60-200 with the process of discordance.