Lundberg M, Jerominski L, Livingston G, Kochenour N, Lee T, Fineman R
Am J Med Genet. 1982 Jan;11(1):31-5. doi: 10.1002/ajmg.1320110105.
Antepartum use of diagnostic ultrasound has markedly reduced radiation exposure of the fetus. Previous investigations have documented the safety of ultrasound, but concern persists regarding its long-term effects. As new methods become available to study possible subtle effects of ultrasound, it is important to reevaluate this technique continually because of its universal use in obstetrics and elsewhere. We report results of in vivo studies of effect of diagnostic ultrasound on the sister chromatid exchange (SCE) frequency in amniotic fluid cells. SCE is a cytogenetic phenomenon believed to be a sensitive indicator of environmental perturbations and chromosome stability. In amniotic fluid cells from six pregnancies without ultrasound exposure and in 34 pregnancies that received varying amount of ultrasound immediately before amniocentesis, there was no difference in SCE frequency in exposed verus nonexposed cells. These data, which appear to confirm again the safety of ultrasound, are reassuring to both patients and clinicians.
产前诊断性超声的使用显著减少了胎儿的辐射暴露。先前的研究已证明超声的安全性，但对其长期影响的担忧依然存在。随着研究超声可能存在的细微影响的新方法不断出现，鉴于其在产科及其他领域的广泛应用，持续重新评估这项技术很重要。我们报告了诊断性超声对羊水细胞姐妹染色单体交换（SCE）频率影响的体内研究结果。SCE是一种细胞遗传学现象，被认为是环境干扰和染色体稳定性的敏感指标。在6例未接受超声检查的妊娠羊水细胞以及34例在羊膜穿刺术前立即接受不同剂量超声检查的妊娠羊水中，暴露细胞与未暴露细胞的SCE频率没有差异。这些数据似乎再次证实了超声的安全性，这让患者和临床医生都感到安心。
