Philipson A, Stiernstedt G
Am J Obstet Gynecol. 1982 Apr 1;142(7):823-8. doi: 10.1016/s0002-9378(16)32526-1.
Most pharmacokinetic studies of antibodies in pregnancy have been carried out at the time of abortion or delivery. Whether such data represent pregnancy as such is not known. The present study compares the pharmacokinetic properties of cefuroxime in seven women during pregnancy, at delivery, and after delivery. After intravenous administration of 750 mg of cefuroxime, levels of the drug in plasma and urine were measured during a period of 8 hours. Levels of cefuroxime in cord plasma and amniotic fluid were registered, as were levels of plasma from the neonates at 6 and 12 hours. Plasma levels were significantly lower during pregnancy than afterward, drug half-life was significantly shorter, and clearance and recovery in urine were significantly higher. Differences, although less consistent, were observed in certain parameters at delivery, as compared to earlier in pregnancy, thus indicating that pharmacokinetic data obtained at delivery may not be typical of pregnancy as such. Passage of cefuroxime across the placenta was well demonstrable in all cases.
大多数关于孕期抗体的药代动力学研究都是在流产或分娩时进行的。这些数据是否能真正代表孕期情况尚不清楚。本研究比较了头孢呋辛在7名女性孕期、分娩时及分娩后的药代动力学特性。静脉注射750毫克头孢呋辛后，在8小时内测量血浆和尿液中的药物水平。记录了脐血血浆和羊水中头孢呋辛的水平，以及新生儿在6小时和12小时时的血浆水平。孕期血浆水平显著低于产后，药物半衰期显著缩短，尿液中的清除率和回收率显著升高。与孕期早期相比，分娩时某些参数也存在差异，尽管不太一致，这表明分娩时获得的药代动力学数据可能并不代表整个孕期的典型情况。在所有病例中均能很好地证明头孢呋辛可通过胎盘。
