Hayasaka S, Ishiguro S I, Shiono T, Okabe H, Mizuno K
Am J Ophthalmol. 1982 Jan;93(1):111-7. doi: 10.1016/0002-9394(82)90709-7.
A scanning electron microscopic study showed that the surface of the nylon used for corneoscleral wound closure was smooth, while the nylon suture thread used to fix the intraocular lens against the iris showed cracks and roughness on its surface. The surface of the nylon thread was also roughened after treatment with bovine iris-ciliary body extracts. The nylon-degrading factor in the extract was nondialyzable, heat-labile, active at acidic pH, and inhibited in part by leupeptin, suggesting that lysosomal enzymes may be a factor in this phenomenon. Of the bovine ocular tissues, ciliary body extract degraded the surface of the nylon thread most significantly. The nylon surface was moderately digested by the retinal pigment epithelial extract, and slightly eroded by the extracts from the iris, sensory retina, and choroid. Corneal and lenticular extracts did not affect the nylon surface. Nylon suture thread may be hydrolyzed by lysosomal enzymes and should be considered a late-degrading suture.
扫描电子显微镜研究表明，用于角膜巩膜伤口闭合的尼龙表面光滑，而用于将人工晶状体固定在虹膜上的尼龙缝合线表面有裂缝且粗糙。用牛虹膜睫状体提取物处理后，尼龙线表面也变得粗糙。提取物中的尼龙降解因子不可透析、对热不稳定、在酸性pH下有活性，并且部分受亮抑酶肽抑制，这表明溶酶体酶可能是这种现象的一个因素。在牛眼组织中，睫状体提取物对尼龙线表面的降解最为显著。视网膜色素上皮提取物对尼龙表面有中度消化作用，虹膜、感觉视网膜和脉络膜的提取物对尼龙表面有轻微侵蚀作用。角膜和晶状体提取物对尼龙表面没有影响。尼龙缝合线可能会被溶酶体酶水解，应被视为一种后期降解的缝合线。
