Ramsey T A, Cox M
Am J Psychiatry. 1982 Apr;139(4):443-9. doi: 10.1176/ajp.139.4.443.
The effects of lithium on renal water and electrolyte transport have generally been considered to be reversible following the cessation of lithium treatment. However, several recent reports have suggested that lithium-induced nephrogenic diabetes insipidus may persist for months or even years after lithium is discontinued. In addition, a number of reports have described the development of renal insufficiency (in association with interstitial nephritis) in some patients who have been chronically treated with lithium. The authors briefly review the effects of lithium on renal tubular transport and critically examine the reports of lithium-induced renal disease.
锂对肾脏水和电解质转运的影响通常被认为在锂治疗停止后是可逆的。然而，最近的一些报告表明，锂诱导的肾性尿崩症在停用锂后可能会持续数月甚至数年。此外，一些报告描述了一些长期接受锂治疗的患者出现肾功能不全（与间质性肾炎相关）的情况。作者简要回顾了锂对肾小管转运的影响，并严格审查了锂诱导的肾脏疾病的报告。
