Franchimont C, Pierard G E, Van Cauwenberge D, Damseaux M, Lapiere C H
Br J Dermatol. 1982 Mar;106(3):305-10. doi: 10.1111/j.1365-2133.1982.tb01728.x.
Metabolic activity and structure of the stroma adjacent to basel cell carcinomas are closely related to cytological aspects and proliferative activity of the neoplastic cells. Basal cell carcinomas without clear evidence for regression compress or infiltrate an apparently normal dermis where cellular replication is low. Conversely regressing zones of basal cell carcinomas are surrounded by a remodelled stroma where fibroblasts and endothelial cells show signs of proliferation. When regression affects the palisaded array of cells, clefts occur between the basal cell carcinoma and the adjacent stroma. Progression of most types of basal carcinomas may proceed by successive extension and partial regression. More than one type of stroma reaction may be present ina single basal cell carcinoma and the overall pattern may be regarded as the result of successive phases of growth and regression of the neoplasm.
基底细胞癌邻近基质的代谢活性和结构与肿瘤细胞的细胞学特征及增殖活性密切相关。无明显消退迹象的基底细胞癌会压迫或浸润细胞复制水平较低的看似正常的真皮。相反，基底细胞癌的消退区域被重塑的基质所包围，其中成纤维细胞和内皮细胞呈现增殖迹象。当消退影响到细胞的栅栏状排列时，基底细胞癌与相邻基质之间会出现裂隙。大多数类型基底癌的进展可能通过连续扩展和部分消退来进行。单个基底细胞癌中可能存在不止一种基质反应类型，整体模式可被视为肿瘤生长和消退连续阶段的结果。
