Ross D A, Glick S D, Meibach R C
Brain Res. 1982 Mar;255(3):341-7. doi: 10.1016/0165-3806(82)90002-5.
Using a modification of the 2-deoxy-D-glucose technique we have studied developmental changes in local cerebral glucose incorporation. The data were analyzed in terms of per cent uptake, relative brain activity and left-right asymmetry for 7 brain regions. We have shown previously that left-right asymmetries exist at birth and now report: (a) that left-right asymmetries change with age, there being both left-to-right and right-to-left maturational gradients in different structures; and (b) that in most brain regions, the more active a structure is relative to the rest of the brain, the more likely that structure is right-biased and vice-versa. Some of these relationships manifest sexual dimorphism. Collectively, these data indicate that there are dynamic relationships between brain activity, brain asymmetry and brain development in the rat.
我们采用改良的2-脱氧-D-葡萄糖技术，研究了局部脑葡萄糖摄取的发育变化。从7个脑区的摄取百分比、相对脑活动和左右不对称性方面对数据进行了分析。我们之前已经表明，出生时就存在左右不对称性，现在报告如下：(a) 左右不对称性随年龄变化，不同结构中存在从左到右和从右到左的成熟梯度；(b) 在大多数脑区，一个结构相对于大脑其他部分越活跃，该结构越可能偏向右侧，反之亦然。其中一些关系表现出性别二态性。总体而言，这些数据表明大鼠的脑活动、脑不对称性和脑发育之间存在动态关系。
