Ross D A, Glick S D, Meibach R C
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1958-61. doi: 10.1073/pnas.78.3.1958.
The 2-deoxy-D-glucose method was used to study asymmetries in cerebral metabolic activity in neonatal rats. Left-right asymmetries in 2-deoxy-D-glucose uptake were observed in hippocampus, diencephalon, cortex, and medulla-pons: 2-deoxy-D-glucose incorporation was greater in right hippocampus, right diencephalon, left cortex, and left medulla-pons. These asymmetries occurred only in females. We also observed neonatal asymmetries in tail position that, in both sexes, were predictive of adult turning preferences; females had right-sided biases in both neonatal and adult characteristics. Collectively these data indicate that cerebral lateralization is sexually dimorphic and is present at birth.
采用2-脱氧-D-葡萄糖法研究新生大鼠大脑代谢活动的不对称性。在海马体、间脑、皮质和延髓脑桥中观察到2-脱氧-D-葡萄糖摄取的左右不对称性：右侧海马体、右侧间脑、左侧皮质和左侧延髓脑桥中的2-脱氧-D-葡萄糖掺入量更高。这些不对称性仅在雌性中出现。我们还观察到新生大鼠尾巴位置的不对称性，在两性中，这种不对称性都能预测成年后的转向偏好；雌性在新生期和成年期的特征上都有右侧偏向。这些数据共同表明，大脑的偏侧化具有性别差异，并且在出生时就已存在。
