羟氯喹对白细胞运动的抑制作用及对免疫复合物性实验性结肠炎的预防作用。

Inhibition of leucocyte motility and prevention of immune-complex experimental colitis by hydroxychloroquine.

作者信息

Rhodes J M, McLaughlin J E, Brown D J, Nuttall L A, Jewell D P

出版信息

Gut. 1982 Mar;23(3):181-7. doi: 10.1136/gut.23.3.181.

DOI:10.1136/gut.23.3.181

PMID:7068043

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1419643/

Abstract

The inhibitory effects of hydroxychloroquine on leucocyte motility have been compared with those of prednisolone. It has been shown to have similar potency to prednisolone as an inhibitor of human neutrophil and monocyte motility. Hydroxychloroquine has then been compared with placebo in the prevention of an immune-complex experimental colitis in rabbits. Rectal biopsies were taken from rabbits 24 hours after initiation of colitis, coded, and graded histologically. The summated gradings for acute inflammation and goblet cell depletion had worsened more in the control rabbits (mean grade +6.7) than in the treated rabbits (mean grade +1.8) P less than 0.05. There was no difference in the mononuclear cell infiltrate between the two groups. Hydroxychloroquine, which is a potent inhibitor of leucocyte motility, effectively prevents the acute inflammatory infiltrate in this experimental colitis model and therefore merits trial in human ulcerative colitis.

摘要

已将羟氯喹对白细胞运动的抑制作用与泼尼松龙的抑制作用进行了比较。结果表明，作为人类中性粒细胞和单核细胞运动的抑制剂，它与泼尼松龙具有相似的效力。然后，在预防兔免疫复合物实验性结肠炎方面，将羟氯喹与安慰剂进行了比较。在结肠炎发作24小时后从兔身上获取直肠活检组织，进行编码，并进行组织学分级。对照兔（平均分级+6.7）的急性炎症和杯状细胞耗竭的总分级比治疗兔（平均分级+1.8）恶化得更严重，P<0.05。两组之间单核细胞浸润没有差异。羟氯喹作为白细胞运动的有效抑制剂，可有效预防该实验性结肠炎模型中的急性炎症浸润，因此值得在人类溃疡性结肠炎中进行试验。