克罗恩病和溃疡性结肠炎中中性粒细胞和单核细胞的运动性
Motility of neutrophils and monocytes in Crohn's disease and ulcerative colitis.
作者信息
Rhodes J M, Jewell D P
出版信息
Gut. 1983 Jan;24(1):73-7. doi: 10.1136/gut.24.1.73.
Abstract
Random motility and chemotaxis of peripheral blood neutrophils and monocytes from patients with Crohn's disease and ulcerative colitis have been measured using a modified Boyden Chamber filter assay. Increased random motility and chemotaxis of monocytes were found in patients with active ulcerative colitis. Monocyte motility was normal in Crohn's disease and no abnormality of neutrophil motility or chemotaxis was found in either disease. Drug therapy with prednisolone or sulphasalazine received in vivo was found to have no effect on the motility of the washed neutrophils and monocytes in vitro. This work adds to the evidence that monocytes are activated in ulcerative colitis but does not support the hypothesis that Crohn's disease is due to an inherent defect in phagocyte motility.
摘要
使用改良的博伊登小室滤膜试验，对克罗恩病和溃疡性结肠炎患者外周血中性粒细胞和单核细胞的随机运动性和趋化性进行了测量。发现活动期溃疡性结肠炎患者的单核细胞随机运动性和趋化性增加。克罗恩病患者的单核细胞运动性正常，两种疾病中均未发现中性粒细胞运动性或趋化性异常。发现体内接受泼尼松龙或柳氮磺胺吡啶药物治疗对体外洗涤的中性粒细胞和单核细胞的运动性没有影响。这项研究进一步证明了溃疡性结肠炎中单核细胞被激活，但不支持克罗恩病是由于吞噬细胞运动性内在缺陷这一假说。
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本文引用的文献
1
The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.抗体与抗原混合物对多形核白细胞的趋化作用。
J Exp Med. 1962 Mar 1;115(3):453-66. doi: 10.1084/jem.115.3.453.
2
Cortisone in ulcerative colitis; final report on a therapeutic trial.可的松治疗溃疡性结肠炎；一项治疗试验的最终报告
Br Med J. 1955 Oct 29;2(4947):1041-8. doi: 10.1136/bmj.2.4947.1041.
3
Monocytes in inflammatory bowel disease: phagocytosis and intracellular killing.炎症性肠病中的单核细胞：吞噬作用与细胞内杀伤
J Clin Pathol. 1980 Oct;33(10):921-5. doi: 10.1136/jcp.33.10.921.
4
Monocytes in inflammatory bowel disease: monocyte and serum lysosomal enzyme activity.炎症性肠病中的单核细胞：单核细胞及血清溶酶体酶活性
Clin Sci (Lond). 1980 Apr;58(4):295-300. doi: 10.1042/cs0580295.
5
Chemotaxis and random migration of polymorphonuclear leukocytes in ulcerative colitis examined by the agarose method.
Scand J Gastroenterol. 1981;16(8):961-6. doi: 10.3109/00365528109181011.
6
In vitro studies on cellular and humoral chemotaxis in Crohn's disease using the under agarose gel technique.使用琼脂糖凝胶技术对克罗恩病的细胞和体液趋化性进行的体外研究。
Gut. 1981 Jul;22(7):566-70. doi: 10.1136/gut.22.7.566.
7
Abnormalities of neutrophil function do not cause the migration defect in Crohn's disease.中性粒细胞功能异常不会导致克罗恩病中的迁移缺陷。
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8
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The cellular evolution of inflammatory granulomata.炎性肉芽肿的细胞演变
J Pathol Bacteriol. 1966 Jul;92(1):163-7. doi: 10.1002/path.1700920117.
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