Fullton J M, Hayes D A, Pimmel R L
J Appl Physiol Respir Environ Exerc Physiol. 1982 Mar;52(3):725-33. doi: 10.1152/jappl.1982.52.3.725.
Retrograde catheter and forced random noise techniques were combined to study the distribution of resistance and compliance in dogs following the inhalation of aerosols containing 2.5 and 5.0 mg/ml of histamine. Mean base-line peripheral resistance was 0.367 cmH2O . l-1 . s, agreeing with previous estimates. After correction for the endotracheal tube, the mean central airway resistance was 0.040 cmH2O . l-1 . s, considerably lower than previous estimates. This discrepancy was attributed to an overcorrection for the endotracheal tube resistance. The lower histamine dose caused a substantial increase in peripheral resistance, a relatively small increase in central resistance, and substantial decreases in total and peripheral compliance. After the higher histamine dose, changes in peripheral resistance and both compliances were similar to those obtained with the lower dose; however, the increase in central resistance was much larger than at the lower dose. The difference between total and peripheral compliance yielded estimates of airway compliance of 0.00306 l/cmH2O before and 0.00104 l/cmH2O after 2.5 mg/ml of histamine.
将逆行导管技术和强迫随机噪声技术相结合，研究了犬吸入含2.5毫克/毫升和5.0毫克/毫升组胺的气雾剂后阻力和顺应性的分布情况。平均基线外周阻力为0.367厘米水柱·升⁻¹·秒，与先前的估计值相符。校正气管插管后，平均中心气道阻力为0.040厘米水柱·升⁻¹·秒，远低于先前的估计值。这种差异归因于对气管插管阻力的过度校正。较低剂量的组胺使外周阻力大幅增加，中心阻力相对小幅增加，总顺应性和外周顺应性大幅降低。较高剂量的组胺作用后，外周阻力和两种顺应性的变化与较低剂量时相似；然而，中心阻力的增加幅度比低剂量时大得多。总顺应性和外周顺应性之间的差异得出，在吸入2.5毫克/毫升组胺之前气道顺应性估计值为0.00306升/厘米水柱，之后为0.00104升/厘米水柱。
