Kimura Y, Motokawa K, Nagata H, Kameda Y, Matsuura S, Mayama M, Yoshida T
J Antibiot (Tokyo). 1982 Jan;35(1):32-8. doi: 10.7164/antibiotics.35.32.
Asparenomycins (ASM) A, B and C, new members of the carbapenem family of antibiotics, are broad spectrum antibiotics with activity against Gram-positive and Gram-negative bacteria. ASM A was bactericidal to both aerobic and anaerobic bacteria, although morphological alterations of ASM A exposed cells differed significantly between Escherichia coli and Bacteroides fragilis; with the former ovoidal forms were produced while with the latter elongated forms were seen. Synergistic activities were observed with a combination of ASM A and ampicillin (ABPC) against various ABPC-resistant bacteria presumably as a result of the inhibition by ASM A of beta-lactamases. ASM A showed relatively weak therapeutic activity against E. coli infected mice, because of instability in body fluids, a common property of the carbapenem family of antibiotics.
天冬霉素（ASM）A、B和C是碳青霉烯类抗生素家族的新成员，是对革兰氏阳性菌和革兰氏阴性菌均有活性的广谱抗生素。ASM A对需氧菌和厌氧菌均有杀菌作用，尽管ASM A处理的细胞在大肠杆菌和脆弱拟杆菌中的形态改变有显著差异；前者产生卵形形态，而后者可见伸长形态。观察到ASM A与氨苄西林（ABPC）联合使用对各种耐ABPC细菌具有协同活性，这可能是由于ASM A对β-内酰胺酶的抑制作用。由于在体液中不稳定，这是碳青霉烯类抗生素家族的共同特性，ASM A对感染大肠杆菌的小鼠显示出相对较弱的治疗活性。
